Tyrosine-protein kinase ABL1

Interactor Gene Name:
ABL1
Interactor protein name:
Tyrosine-protein kinase ABL1
Uniprot ID:
P00519
Receptor (species):
Synthetic peptide
Interactor (species):
Human
Experimental System:
in vitro
Detection Method:
Peptide array
Interaction Domain (P2X7):
N-terminus 114-126
Published (year):
2007
Publication (PubMed):
Wu C (2007)
Protein Structure of Interactor:
RSCB PDB
Sequence:
NCBI Gene
Expression Profile:
EMBL-EBI Expression Atlas
Disease Pathways:
OMIM; GAD

ABL1 is a cytoplasmic and nuclear non-receptor tyrosine kinase, which contains Src homogy 2 (SH2) and SH3 domains, a DNA-binding domain, and an actin binding and bundling domain.

ABL1 is involved in actin remodelling, cell adhesion and motility, differentiation, DNA damage and immune responses.

ABL1 is a proto-oncogene; its activity is negatively regulated by the SH3 domain. Deletion of SH3 turns it into an oncogene. Several chromosome translocations activate ABL1 in hematopoietic malignancies (e.g. chronic myeloid leukemia).