P2X purinoceptor 4

Interactor Gene Name:
P2RX4
Interactor protein name:
P2X purinoceptor 4
Uniprot ID:
Human; Mouse; Rat
Identifed in (species):
Human (1, 3, 4, 5), Mouse (1, 2)
Cell Type/ Tissue:
HEK 293 (1, 5), BMDM (1, 2), tsA 201 (3), HIGK (4)
Receptor (species):
Rat (1, 3), Mouse (1, 2, 5) Human (4)
Interactor (species):
Rat (1, 3), Mouse (1, 2, 5) Human (4)
Experimental System:
Transgenic / endogenous (co)-expression
Detection Method:
Co-IP / WB (1-5), FRET (5)
Interaction Domain (P2X7):
full-length, C-terminus 418-595
Published (year):
2007 (1) 2009 (2) 2011 (3) 2013 (4) 2015 (5)
Publication (PubMed):
1, Guo C (2007); 2, Boumechache M (2009); 3, Antonio LS (2011); 4, Hung SC (2013) 5, Perez-Flores G (2015)
Protein Structure of Interactor:
RSCB PDB
Sequence:
Human; Mouse; Rat
Expression Profile:
EMBL-EBI Expression Atlas
Disease Pathways:
OMIM; GAD

P2X4 is a member of the P2X receptor family of ATP-gated ion channels. It displays a widespread tissue distribution in mammals and plays roles in neuropathic pain, inflammation, flow-dependent control of vascular tone and long-term potentiation.