NLR family protein 1

Interactor Gene Name:
Nlrp1
Interactor protein name:
NLR family protein 1
Uniprot ID:
D9I2G4
Identifed in (species):
Rat
Cell Type/ Tissue:
Primary neurons
Receptor (species):
Rat
Interactor (species):
Rat
Experimental System:
endogenous expression
Detection Method:
Co-IP / WB
Published (year):
2009
Publication (PubMed):
Silverman WR (2009)
Sequence:
NCBI Gene
Expression Profile:
EMBL-EBI Expression Atlas
Disease Pathways:
OMIM

NLRP1 belongs to the NOD-like receptor (NLR) family. NLRs are intracellular pattern recognition receptors (PRRs) and are responsible for recognition of intracellular pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs).

Recognition of PAMPs or DAMPs by NLRP1 triggers assembly of NLRP1 inflammasome which is important for caspase-1 activation and processing of pro-inflammatory cytokines e.g. IL-1β.