NACHT, LRR and PYD domains-containing protein 2 (NRLP2)

Interactor Gene Name:
NLRP2
Interactor protein name:
NACHT, LRR and PYD domains-containing protein 2
Uniprot ID:
Q9NX02
Identifed in (species):
Human
Cell Type/ Tissue:
Astrocytes
Receptor (species):
Human
Interactor (species):
Human
Experimental System:
Endogenous expression
Detection Method:
Co-IP / WB
Published (year):
2013
Publication (PubMed):
Minkiewicz J (2013)
Sequence:
NCBI Gene
Expression Profile:
EMBL-EBI Expression Atlas
Disease Pathways:
OMIM; GAD

NRLP2 belongs to the nucleotide-binding oligomerization domain (NOD)-like receptor family of intracellular pattern recognition receptors, which play important roles in innate and adaptive immunity.

NRLP2 associates with Apoptosis-associated speck-like protein containing a CARD (ASC) and caspase-1 and inhibits nuclear factor kappa B (NFkB) signalling. Additionally, together with ASC, P2X7, pannexin-1 and caspase-1 forms a functional inflammasome.

NRLP2 is a member of the mammalian maternal effect genes and is required for early embryonic development in the mouse.