Integrin beta-2

Interactor Gene Name:
ITGB2
Interactor protein name:
Integrin beta-2
Uniprot ID:
P05107
Identifed in (species):
Human
Cell Type/ Tissue:
HEK 293
Receptor (species):
Rat
Interactor (species):
Human
Experimental System:
Stable transgenic expression
Detection Method:
Co-IP / Mass Spec
Published (year):
2001
Publication (PubMed):
Kim M (2001)
Protein Structure of Interactor:
RSCB PDB
Sequence:
NCBI Gene
Expression Profile:
EMBL-EBI Expression Atlas
Disease Pathways:
OMIM; GAD

Integrin beta-2 belongs to the integrin beta chain family of proteins, which are cell adhesion proteins composed of an alpha and beta chain. It associates with several different chains (e.g. alpha L chain to form the integrin lymphocyte function-associated antigen 1 (LFA-1)), and forms receptors for different ligands (e.g. intercellular adhesion molecules (ICAMs), vascular cell adhesion protein 1 (VCAM-1)).

Integrins are involved in immunity, wound healing, haemostasis and development.