Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1

Interactor Gene Name:
PPIP5K1
Interactor protein name:
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
Uniprot ID:
Q6PFW1
Identifed in (species):
Human
Cell Type/ Tissue:
THP-1
Receptor (species):
Human
Interactor (species):
Human
Experimental System:
Endogenous expression
Detection Method:
Co-IP / Mass Spec
Published (year):
2009
Publication (PubMed):
Gu BJ (2009)
Protein Structure of Interactor:
RSCB PDB
Sequence:
NCBI Gene
Expression Profile:
EMBL-EBI Expression Atlas
Disease Pathways:
OMIM

PPIP5K1 is a bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation.

PPIP5K1 phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, it phosphorylates PP-InsP5, produced by IP6Ks from InsP6, at position 1 or 3 PP-InsP5 to produce (PP)2-InsP4.

PPIP5K1 is activated when cells are exposed to hyperosmotic stress.