Heat shock protein HSP 90-beta

Interactor Gene Name:
HSP90AB1
Interactor protein name:
Heat shock protein HSP 90-beta
Uniprot ID:
P08238
Identifed in (species):
Human (1, 2, 3) Rat (4)
Cell Type/ Tissue:
HEK 293 (1, 2, 3) PC12 (4)
Receptor (species):
Rat (1,2, 4) Human (3)
Interactor (species):
Human (1, 2, 3, 4)
Experimental System:
Stable transgenic / endogenous expression
Detection Method:
Co-IP / Mass Spec (1, 3); Co-IP / Wb (2, 4)
Published (year):
2001 (1) 2003 (2) 2009 (3) 2013 (4)
Publication (PubMed):
1, Kim M (2001) 2, Adinolfi E (2003) 3, Gu BJ (2009) 4, Franco MC (2013)
Protein Structure of Interactor:
RSCB PDB
Sequence:
NCBI Gene
Expression Profile:
EMBL-EBI Expression Atlas
Disease Pathways:
OMIM; GAD

Heat shock protein HSP 90-β is a member of the heat shock protein 90 family of chaperones. It is constitutively expressed and has an intrinsic ATPase activity.

HSP90-β is involved in regulation of protein homeostasis, signal transduction, apoptosis and inflammation. It undergoes a functional cycle which probably induces conformational changes in the client proteins causing their activation/inactivation.