Heat shock cognate 71 kDa protein

Interactor Gene Name:
HSPA8 (HSC70)
Interactor protein name:
Heat shock cognate 71 kDa protein
Uniprot ID:
P11142
Identifed in (species):
Human
Cell Type/ Tissue:
HEK 293
Receptor (species):
Rat
Interactor (species):
Human
Experimental System:
Stable transgenic expression
Detection Method:
Co-IP / Mass Spec
Published (year):
2001
Publication (PubMed):
Kim M (2001)
Protein Structure of Interactor:
RSCB PDB
Sequence:
NCBI Gene
Expression Profile:
EMBL-EBI Expression Atlas
Disease Pathways:
OMIM; GAD

Hsc70 belongs to the heat shock protein (HSP) 70 family of cytoplasmic chaperones. It is involved in protein homeostasis, facilitates correct protein folding, maturation, assembly, disassembly, translocation and degradation. It possesses an intrinsic ATPase activity.

Hsc70 plays an important role in the aging process and aging-related diseases. It is secreted from stressed cells and plays a role in inflammation (interacts with TLR2/TLR4), cancer cell proliferation and sperm storage.