Hsc70 belongs to the heat shock protein (HSP) 70 family of cytoplasmic chaperones. It is involved in protein homeostasis, facilitates correct protein folding, maturation, assembly, disassembly, translocation and degradation. It possesses an intrinsic ATPase activity.
Hsc70 plays an important role in the aging process and aging-related diseases. It is secreted from stressed cells and plays a role in inflammation (interacts with TLR2/TLR4), cancer cell proliferation and sperm storage.