Heat shock 70 kDa protein 1A/1B

Interactor Gene Name:
HSPA1A, HSPA1B
Interactor protein name:
Heat shock 70 kDa protein 1A/1B
Uniprot ID:
P08107
Identifed in (species):
Human (1, 2)
Cell Type/ Tissue:
HEK 293 (1, 2)
Receptor (species):
Rat (1)
Interactor (species):
Human (1, 2)
Experimental System:
stable transgenic expression
Detection Method:
Co-IP / Mass Spec (1, 2)
Published (year):
2001 (1); 2009 (2)
Publication (PubMed):
1, Kim M (2001); 2, Gu BJ (2009)
Protein Structure of Interactor:
RSCB PDB
Sequence:
NCBI Gene
Expression Profile:
EMBL-EBI Expression Atlas
Disease Pathways:
OMIM; GAD

In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage.