Growth factor receptor-bound protein 2

Interactor Gene Name:
GRB2
Interactor protein name:
Growth factor receptor-bound protein 2
Uniprot ID:
P62993
Identifed in (species):
Human
Receptor (species):
Synthetic peptide
Interactor (species):
Human
Experimental System:
in vitro
Detection Method:
Peptide array
Interaction Domain (P2X7):
N-terminus 114-126
Published (year):
2007
Publication (PubMed):
Wu C (2007)
Protein Structure of Interactor:
RSCB PDB
Sequence:
NCBI Gene
Expression Profile:
EMBL-EBI Expression Atlas
Disease Pathways:
OMIM; GAD

GRB2 is a ubiquitously expressed adaptor protein and a member of the GRB2 family. It contains one Src homology 2 (SH2) and two SH3 domains.

GRB2 plays a critical role in early development. It is involved in intracellular signalling pathways (e.g. Ras, MAPK).  It plays a role in cell cycle progression, actin-based cell motility, angiogenesis and cancer metastasis.