Epithelial membrane protein 1

Interactor Gene Name:
EMP1
Interactor protein name:
Epithelial membrane protein 1
Uniprot ID:
P54849
Identifed in (species):
Human
Cell Type/ Tissue:
HEK
Receptor (species):
Rat
Interactor (species):
Human
Experimental System:
transgenic co-expression
Detection Method:
GST pull-down
Interaction Domain (P2X7):
C-terminus 356-595
Experimental Confirmation:
co-purifcation His-tag
Published (year):
2002
Publication (PubMed):
Wilson HL (2002)
Sequence:
NCBI Gene
Expression Profile:
EMBL-EBI Expression Atlas
Disease Pathways:
OMIM; GAD

EMP1 belongs to the peripheral myelin protein 22 (PMP22) family (together with EMP-2 and EMP-3), which are tetraspan transmembrane proteins.

It is involved in the differentiation of multiple cell types, including progenitor/pre-B cells, neurons, podocytes and spinal chondrocytes.  A role in tumorigenesis and tumour metastasis has been also reported.