Ephrin-B3

Interactor Gene Name:
EFNB3
Interactor protein name:
Ephrin-B3
Uniprot ID:
Q15768
Identifed in (species):
Human
Cell Type/ Tissue:
Liver cDNA library
Receptor (species):
Human
Interactor (species):
Human
Detection Method:
Yeast two-hybrid
Published (year):
2011
Publication (PubMed):
Wang J (2011)
Protein Structure of Interactor:
RSCB PDB
Sequence:
NCBI Gene
Expression Profile:
EMBL-EBI Expression Atlas
Disease Pathways:
OMIM; GAD

Ephrin-B3 is a cell-surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development.

Ephrin-B3 binds to Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. It may play a pivotal role in forebrain function. Ephrin-B3 has been shown to bind to, and induce the collapse of, commissural axons/growth cones in vitro. It may also play a role in constraining the orientation of longitudinally projecting axons.