Alpha-actinin 4

Interactor Gene Name:
ACTN4
Interactor protein name:
alpha-actinin 4
Uniprot ID:
O43707
Identifed in (species):
Human
Cell Type/ Tissue:
HEK293
Receptor (species):
Rat
Interactor (species):
Human
Experimental System:
stable transgenic expression
Detection Method:
Co-IP / Mass Spec
Published (year):
2001
Publication (PubMed):
Kim M (2001)
Protein Structure of Interactor:
RSCB PDB
Sequence:
NCBI Gene
Expression Profile:
EMBL-EBI Expression Atlas
Disease Pathways:
OMIM; GAD

Non-muscle alpha-actinin is a ubiquitously expressed cytoskeletal protein, which belongs to the superfamily of filamentous actin (F-actin) cross-linking proteins. In addition to F-actin it also interacts with many cytoskeletal and transmembrane proteins.

Alpha-actinin is involved in cytoskeletal organisation, motility, migration of immune cells, cancer cell progression and metastasis.